Limiting global warming to less than 1.5 or 2°C requires the removal of hundreds of gigaton tons of CO2 from the atmosphere by the end of this century. Ocean alkalinity enhancement (OAE) is one of the most promising approaches for removing climate-relevant quantities of atmospheric CO2. However, OAE is subject to gradual and incomplete air-sea CO2 exchange that reduces its efficiency. A critical knowledge gap exists regarding where in the ocean and in which seasons OAE should be deployed to maximize its efficiency. In this presentation, I will present a fine-grained map of OAE efficiency that covers four seasons, generated from 2760 CESM2 (Community Earth System Model, version 2) simulations, which allows us to identify places and seasons that are most suitable for OAE deployment. I will also show the spread of CO2 uptake that will help to determine the domain size required for regional ocean models. A conceptual box model that provides a mechanistic understanding of air-sea CO2 exchange in the Lagrangian frame will also be discussed.